MW 342.35 g/mol, Purity >99%. Highly potent, selective CCR3 antagonist (IC₅₀ = 2.5 μM). Displays 250-fold selectivity for CCR3 vs. CXCR1, CXCR2, CCR1 and CCR7 receptors. Potent inhibitor of Ca²+ mobilization induced by eotaxin, eotaxin-2 and MCP-4 in human eosinophils (IC₅₀ values are 210, 90 and 80 nM, respectively).
The product is subject to the following: Abcam Restricted Use Statement